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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
28.18
Human Site:
Y954
Identified Species:
44.29
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y954
N
E
Q
S
L
L
E
Y
L
E
K
Q
R
N
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y954
N
E
Q
S
L
L
E
Y
L
E
K
Q
R
N
R
Dog
Lupus familis
XP_531814
1283
145094
E915
I
T
R
N
L
P
E
E
Y
E
L
K
S
T
K
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y951
N
E
Q
S
L
L
E
Y
L
D
K
Q
R
S
R
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y954
N
E
Q
S
L
L
E
Y
L
D
K
Q
R
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Y1060
V
E
E
D
F
R
T
Y
L
D
K
Q
R
K
L
Frog
Xenopus laevis
NP_001089247
1340
149481
Y934
A
E
Q
D
L
N
E
Y
L
D
K
Q
R
K
R
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
Y955
C
E
R
D
L
Q
D
Y
L
D
R
Q
K
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
L829
K
A
N
K
S
Y
T
L
E
G
Q
T
K
G
K
Honey Bee
Apis mellifera
XP_392346
1120
127429
Y759
H
G
S
D
K
K
R
Y
Q
I
E
I
P
D
S
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
F825
N
T
K
V
S
S
S
F
E
L
K
S
R
R
K
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
Y926
T
K
D
R
L
Q
E
Y
L
D
K
Q
K
K
R
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
S919
F
Y
R
Y
W
T
P
S
I
K
K
F
L
G
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
H908
F
E
S
S
L
K
K
H
L
K
E
Q
R
K
L
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
N881
T
L
E
E
D
L
K
N
R
L
C
Q
K
F
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
20
N.A.
86.6
86.6
N.A.
N.A.
40
66.6
40
N.A.
0
6.6
20
46.6
P-Site Similarity:
100
N.A.
100
46.6
N.A.
100
100
N.A.
N.A.
53.3
73.3
73.3
N.A.
20
26.6
40
66.6
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
27
7
0
7
0
0
40
0
0
0
7
7
% D
% Glu:
0
54
14
7
0
0
47
7
14
20
14
0
0
0
7
% E
% Phe:
14
0
0
0
7
0
0
7
0
0
0
7
0
7
0
% F
% Gly:
0
7
0
0
0
0
0
0
0
7
0
0
0
14
0
% G
% His:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
0
0
0
0
7
7
0
7
0
0
0
% I
% Lys:
7
7
7
7
7
14
14
0
0
14
60
7
27
34
20
% K
% Leu:
0
7
0
0
60
34
0
7
60
14
7
0
7
0
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
34
0
7
7
0
7
0
7
0
0
0
0
0
14
0
% N
% Pro:
0
0
0
0
0
7
7
0
0
0
0
0
7
0
0
% P
% Gln:
0
0
34
0
0
14
0
0
7
0
7
67
0
0
0
% Q
% Arg:
0
0
20
7
0
7
7
0
7
0
7
0
54
7
47
% R
% Ser:
0
0
14
34
14
7
7
7
0
0
0
7
7
14
7
% S
% Thr:
14
14
0
0
0
7
14
0
0
0
0
7
0
7
0
% T
% Val:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
0
7
0
60
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _